ExiTron MyoC 8000

Myocardial CT agent

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ExiTron MyoC 8000 CT contrast agent (1 x 5 injections): 130 - 095 - 701
ExiTron MyoC 8000 CT contrast agent (5 x 5 injections): 130 - 095 - 702

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ExiTron MyoC 8000 is an innovative nanoparticulate agent optimized for CT studies of the myocardium. Its accumulation in healthy myocardial tissue as well as its high iodine concentration and long blood half-life enable visualization of pathological changes of the myocardium as well as functional cardiac imaging.

The unique nanoparticulate agent for CT of the myocardium:

  • Optimally enhances the myocardium and allows detection of pathological changes therein
  • Is completely cleared within a day enabling multiple injections in longitudinal studies
  • Has a high biological tolerability allowing studies even in weak animals with severe cardiac pathologies
  • ExiTron MyoC 8000 is Viscover's leading agent for CT studies of the myocardium

Apply ExiTron MyoC 8000 to:

  • Effectively visualize pathological changes of the myocardium, e.g. infarction
  • Quantify infarct size
  • Investigate functional cardiac parameters
  • Perform longitudinal CT studies
  • Obtain optimal CT images at low injection volume
Physico-chemical properties and structure
Mean hydrodynamic diameter:

~300 nm

Hounsfield units (undiluted agent):

~8000 HU

Schematic diagram of an ExiTron MyoC 8000 nanoparticle

ExiTron MyoC 8000 CT imaging of the myocardium
Axial, coronal and sagittal CT images (from left to right) of a healthy mouse (upper row) and a mouse model of myocardial infarction (lower row). The red arrows indicate the non-enhanced infarct region.
Selected references
  1. Sawall, S. et al. (2017) In Vivo Quantification of Myocardial Infarction in Mice using Micro-CT and a Novel Blood Pool Agent. Contrast Media Mol Imaging. https://doi.org/10.1155/2017/2617047.
  2. Bajarano, J. et al. (2018) Bejarano, J. et al. (2018) Nanoparticles for diagnosis and therapy of atherosclerosis and myocardial infarction: evolution toward prospective theranostic approaches. Theranostics 8 (17): 4710-473.
  3. Sawall, S. et al. (2016) CT imaging of myocardial infarction in mice using a novel iodine-based contrast agent. World Molecular Imaging Congress Meeting, New York, USA.
  4. Kraupner, A. et al. (2014) In vivo evaluation of a myocardial infarction in small animals using a novel CT blood pool imaging agent. World Molecular Imaging Congress Meeting, Seoul, South Korea.
Further information