FeraSpin Series

Nanoparticle MRI research toolbox

Order no:

FeraSpin XS MRI agent (1 x 5 injections): 130 - 095 - 140
FeraSpin XS MRI agent (5 x 5 injections): 130 - 095 - 141

FeraSpin S MRI agent (1 x 5 injections): 130 - 095 - 166
FeraSpin S MRI agent (5 x 5 injections): 130 - 095 - 167

FeraSpin M MRI agent (1 x 5 injections): 130 - 095 - 168
FeraSpin M MRI agent (5 x 5 injections): 130 - 095 - 169

FeraSpin L MRI agent (1 x 5 injections): 130 - 095 - 170
FeraSpin L MRI agent (5 x 5 injections): 130 - 095 - 171

FeraSpin XL MRI agent (1 x 5 injections): 130 - 095 - 172
FeraSpin XL MRI agent (5 x 5 injections): 130 - 095 - 173

FeraSpin XXL MRI agent (1 x 5 injections): 130 - 095 - 174
FeraSpin XXL MRI agent (5 x 5 injections): 130 - 095 - 175

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The FeraSpin Series is a product family of six size-selected agents derived from FeraSpin R:
FeraSpin XS to FeraSpin XXL. The identical chemical composition and ultra-narrow size distribution of these fractions allows for fine-tuning of the pharmacologic profile according to your own innovative applications.

The unique series of size-selected superparamagnetic iron oxide nanoparticles:

  • Is analogous to human clinical agents
  • Encompasses particle fractions ranging from ultrasmall to a large size
  • Offers tunable T1 and T2/T2* relaxation properties
  • The FeraSpin Series is Viscover's unique and powerful toolbox for nanoparticle MRI research

Apply the FeraSpin Series to

  • Adjust your unique MR contrast agent for extended circulation, or macrophage and organ-specific uptake by the liver and spleen
  • Perform effective experiments in MR physics, sequence development and nanoparticle physiology

Characteristics of the FeraSpin Series with respect to particle size

FeraSpin
Mean particle size
(hydrodynamic diameter)
Relaxivity r2/r1
(in water 37 °C, 1.41 T )
XS
10-20 nm
3-5
S
20-30 nm
5-9
M
30-40 nm
9-22
L
40-50 nm
22-32
XL
50-60 nm
32-39
XXL
60-70 nm
39-46
FeraSpin Series tunable MRI Contrast
FeraSpin XS, M, and XL (top to bottom) accumulated in mouse liver Kupffer cells leading to T2* hypointensity of healthy liver tissue (left column: pre-contrast, right column: 30 min. post inject) Accumulation and T2* effect clearly increase with particle size.
Mouse whole-body T1-weighted MR angiography using FeraSpin XS.
Left: FeraSpin XS, M, and XL (top to bottom) accumulated in mouse liver Kupffer cells leading to T2* hypointensity of healthy liver tissue (left column: pre-contrast, right column: 30 min. post inject) Accumulation and T2* effect clearly increase with particle size.
Right: Mouse whole-body T1-weighted MR angiography using FeraSpin XS.
Selected references
  1. Lohrke, J. et al. (2008) Characterization of superparamagnetic iron oxide nanoparticles by asymmetrical flow-field-flow-fractionation. Nanomedicine 3: 437-452.
  2. Allkemper,T. et al. (2002) Contrast-enhanced blood-pool MR angiography with optimized iron oxides: effect of size and dose on vascular contrast enhancement in rabbits. Radiology 223: 432-438.
  3. Tsuda, N. et al. (2005) Potential of superparamagnetic iron oxide in the differential diagnosis of metastasis and inflammation in bone marrow: experimental study. Invest. Radiol. 40: 676-681.
  4. Metz, S. et al. (2004) Capacity of human monocytes to phagocytose approved iron oxide MR contrast agents in vitro. Eur. Radiol. 14: 1851-1858.
  5. Ludwig, F. et al. (2012) Optimization of Magnetic Nanoparticles for Magnetic Particle Imaging. IEEE Transactions on Magnetics. 48(11): 3780-3783.