GadoSpin P

MR angiography agent

Order no:

GadoSpin P MRI contrast agent (1 x 5 injections): 130 - 095 - 136
GadoSpin P MRI contrast agent (5 x 5 injections): 130 - 095 - 137

price per item:
€495.00
Excluding VAT and shipping costs

GadoSpin P is a long-circulating imaging agent for magnetic resonance angiography (MRA). It is based on a high molecular weight polymer that does not extravasate from intact blood vessels.

The unique polymeric gadolinium chelate agent:

  • Is based on a linear polymer of a tailored molecular weight
  • Has a long blood half-life, remaining in the vasculature for a prolonged period of time
  • Prevents a loss in vessel contrast over time as seen with monomers
  • Enables higher resolution images through a longer steady state period and a wide acquisition timeframe
  • GadoSpin P is Viscover's leading blood pool agent for MR angiography
  • Apply GadoSpin P to:

    • Effectively visualize healthy vasculature
    • Visualize and quantify vascular abnormalities in tumors and inflammation
    • Harness the full potential of your imaging device to investigate microvessels
    Physico-chemical properties and structure

    Relaxivity (37 °C, 1.41T)

    In water:

    r1 = 10 L mmol-1 s-1
    r2 = 12 L mmol-1 s-1

    Molecular weight:

    ~200,000 g mol-1

    Schematic diagram of GadoSpin P:

GadoSpin P MR angiography
Whole-body T1-weighted MR angiography of a mouse injected with GadoSpin P reveals vascular fine structure.
Top:

Whole-body T1-weighted MR angiography of a mouse injected with GadoSpin P reveals vascular fine structure.

Right:

Timecourse of the signal intensity in mouse blood after injection of GadoSpin P compared to conventional Gd-DTPA. Due to its longer blood pool phase, GadoSpin P allows for a sharper delineation of blood vessels.

Timecourse of the signal intensity in mouse blood after injection of GadoSpin P compared to conventional Gd-DTPA
Due to its longer blood pool phase, GadoSpin P allows for a sharper delineation of blood vessels.
Selected references
  1. Ahn, J.H. et al. (2019) Meningeal lymphatic vessels at the skull base drain cerebrospinal fluid. Nature 572(7767): 62-66.
  2. Govaerts, K. et al. (2013) Towards quantitative evaluation of vascular alterations in mice using MR angiography.
    Front. Neuroinform. doi: 10.3389/conf.fninf.2013.10.00021.
  3. Yang, L.et al. (2013) Evaluating glymphatic pathway function utilizing clinically relevant intrathecal infusion of CSF tracer. J. Transl. Med. 11: 107.
  4. Iliff, J.J. et al. (2013) Brain-wide pathway for waste clearance captured by contrast-enhanced MRI. J Clin Invest. 123(3): 1299-309.
Further information