GadoSpin P

MR angiography agent

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GadoSpin P MRI contrast agent (1 x 5 injections): 130 - 095 - 136
GadoSpin P MRI contrast agent (5 x 5 injections): 130 - 095 - 137

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GadoSpin P is a long-circulating imaging agent for magnetic resonance angiography (MRA). It is based on a high molecular weight polymer that does not extravasate from intact blood vessels.

The unique polymeric gadolinium chelate agent:

  • Is based on a linear polymer of a tailored molecular weight
  • Remains in the vasculature with a long blood half-life
  • Prevents a loss in vessel contrast over time as seen with monomers
  • Enables higher resolution through a longer steady state period and a wide acquisition timeframe
  • GadoSpin P is Viscover's leading blood pool agent for MR angiography
  • Discover an experimental alternative to GadoSpin D for dynamic contrast-enhanced (DCE) MRI studies
Physico-chemical properties and structure

Relaxivity (37 °C, 1.41T)

In water:

r1 = 10 L mmol-1 s-1
r2 = 12 L mmol-1 s-1

Molecular weight:

~200,000 g mol-1

Schematic diagram of GadoSpin P:

GadoSpin P MR angiography
Whole-body T1-weighted MR angiography of a mouse injected with GadoSpin P reveals vascular fine structure.
Top:

Whole-body T1-weighted MR angiography of a mouse injected with GadoSpin P reveals vascular fine structure.

Right:

GadoSpin P allows for a sharper delineation of blood vessels due to its longer blood pool phase compared to conventional extracellular agents (Gd-DTPA).

GadoSpin P allows for a sharper delineation of blood vessels due to its longer blood pool phase compared to conventional extracellular agents (Gd-DTPA).
Selected references
  1. Kirchherr, A.K. et al. (2012) Characterization of a novel gadolinium-based high molecular weight polymer as an intravascular MR contrast agent. Proc. Intl. Soc. Mag. Reson. Med. 20, Melbourne, Australia.
  2. Govaerts, K. et al. (2013) Towards quantitative evaluation of vascular alterations in mice using MR angiography.
    Front. Neuroinform. doi: 10.3389/conf.fninf.2013.10.00021.
  3. Iliff, J.J. et al. (2013) Brain-wide pathway for waste clearance captured by contrast-enhanced MRI. J Clin Invest. 123(3): 1299-309.