GadoSpin F

Atherosclerosis imaging MRI agent

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GadoSpin F MRI contrast agent (1 x 5 injections): 130 - 095 - 162
GadoSpin F MRI contrast agent (5 x 5 injections): 130 - 095 - 163

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GadoSpin F is a unique MRI agent developed for atherosclerosis imaging. It contains a hydrophobic targeting moiety for high protein binding affinity. The agent accumulates in atherosclerotic plaques and enables direct T1-weighted visualization of plaque burden.

The unique amphiphilic agent for plaque imaging:

  • Contains a hydrophobic targeting moiety
  • Accumulates in atherosclerotic plaques
  • Leads to significant T1 positive enhancement in the vascular system
  • GadoSpin F is Viscover’s leading MRI agent for cardiovascular disease imaging
  • Alternatively, benefit from GadoSpin F:

    • For efficient lymph node and inflammation imaging based on its selective enrichment
    • By easily performing an additional angiography scan during GadoSpin F's extended blood pool phase
    Physico-chemical properties and structure

    Relaxivity (37 °C, 1.5 T)

    In plasma:

    r1 = 18 L mmol-1 s-1
    r2 = 31 L mmol-1 s-1

    In water:

    r1 = 15 L mmol-1 s-1
    r2 = 20 L mmol-1 s-1

    Molecular weight:

    ~1,300 g mol-1

    Schematic diagram of GadoSpin F:

    GadoSpin F atherosclerosis and vascular imaging

    Top: Accumulation of GadoSpin F in atherosclerotic plaque of a WHHL rabbit 6 hours (left) and 24 h (right) post injection, as measured by as measured by T1-weighted MRI (TFL IR, 1.5 T).

    Bottom: Axial Flash MR images of an ApoE-/-mouse pre (left) and 24 hours post (right) injection of GadoSpin F. The signal intensity of thr descending aorta (red arrows) increases due to GadoSpin F accumulation in atherosclerotic plaque.

    Selected references
    1. Jung, C. et al. (2017) Quantitative and qualitative estimation of atherosclerotic plaque burden in vivo at 7T MRI using Gadospin F in comparison to en face preparation evaluated in ApoE KO mice. PlosOne 12(8).
    2. Christiansen, S.I. (2015) Quantitative Diagnostik und Monitoring sowie qualitative Charakterisierung atherosklerotischer Plaques in ApoE-KO-Mäusen in der MRT mittels GadoSpin F im Vergleich zu μCT und
      en face-Präparation. PhD thesis.
    3. Niessen, H. G. et al. (2011) Visualizing atherosclerotic plaques in mice with a lipophilic MR contrast agent. International Society for Magnetic Resonance Imaging in Medicine Meeting, Montreal, Canada.
    4. Zheng, J. et al. (2008) Targeted contrast agent helps to monitor advanced plaque during progression: a magnetic resonance imaging study in rabbits. Invest. Radiol. 43: 49-55.
    Further information