GadoSpin F

Atherosclerosis imaging MRI agent

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GadoSpin F MRI contrast agent (1 x 5 injections): 130 - 095 - 162
GadoSpin F MRI contrast agent (5 x 5 injections): 130 - 095 - 163

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price per item:
480.00
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GadoSpin F is a unique MRI agent developed for atherosclerosis imaging. It contains a hydrophobic targeting moiety for high protein binding affinity. The agent accumulates in atherosclerotic plaques and enables direct T1-weighted visualization of plaque burden.

The unique amphiphilic agent for plaque imaging:

  • Contains a hydrophobic targeting moiety
  • Accumulates in atherosclerotic plaques
  • Leads to significant T1 positive enhancement in atherosclerotic vasculature
GadoSpin F is Viscover’s leading MRI agent for cardiovascular disease imaging

Alternatively, benefit from GadoSpin F:

  • For efficient lymph node and inflammation imaging based on its selective enrichment
  • By easily performing an additional angiography scan during GadoSpin F's extended blood pool phase
Physico-chemical properties and structure

Relaxivity (37 °C, 1.5 T)

In plasma:

r1 = 18 L mmol-1 s-1
r2 = 31 L mmol-1 s-1

In water:

r1 = 15 L mmol-1 s-1
r2 = 20 L mmol-1 s-1

Molecular weight:

~1,300 g mol-1

Schematic diagram of GadoSpin F:

GadoSpin F atherosclerosis and vascular imaging
Accumulation of GadoSpin F in WHHL rabbit atherosclerotic plaque as measured by T1-weighted MRI (TFL IR, 1.5 T) 6 hours after injection
... and 24 hours after injection
High-resolution T1-weighted MRI of vasculature in mouse at 1.5 T using GadoSpin F.
Top:

Accumulation of GadoSpin F in WHHL rabbit atherosclerotic plaque as measured by T1-weighted MRI (TFL IR, 1.5 T) 6 and 24 hours after injection.

Left:

High-resolution T1-weighted MRI of vasculature in mouse at 1.5 T using GadoSpin F.

Selected references
  1. Jung, C. et al. (2014) GadoSpin F-enhanced magnetic resonance imaging for diagnosis and monitoring of atherosclerosis: validation with transmission electron microscopy and x-ray fluorescence imaging in the apolipoprotein e-deficient mouse. Mol Imaging. doi: 10.2310/7290.2014.00039.
  2. Christiansen, S.I. (2015) Quantitative Diagnostik und Monitoring sowie qualitative Charakterisierung atherosklerotischer Plaques in ApoE-KO-Mäusen in der MRT mittels GadoSpin F im Vergleich zu μCT und
    en face-Präparation. PhD thesis.
  3. Zheng, J. et al. (2008) Targeted contrast agent helps to monitor advanced plaque during progression: a magnetic resonance imaging study in rabbits. Invest. Radiol. 43: 49-55.
  4. Raatschen, H.J. et al. (2006) MRI tumor characterization using Gd-GlyMe-DOTA-perfluorooctyl-mannose conjugate (Gadofluorine M), a protein-avid contrast agent. Contrast Media Mol. Imaging 1: 113-120.

 
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