Atherosclerosis imaging MRI agent
GadoSpin™ F MRI contrast agent (1 x 5 injections): 130 - 095 - 162
GadoSpin™ F MRI contrast agent (5 x 5 injections): 130 - 095 - 163
GadoSpin F is a unique MRI agent developed for atherosclerosis imaging. It contains a hydrophobic targeting moiety for high protein binding affinity. The agent accumulates in atherosclerotic plaques and enables direct T1-weighted visualization of plaque burden.
The unique amphiphilic agent for plaque imaging:
- Contains a hydrophobic targeting moiety
- Accumulates in atherosclerotic plaques
- Leads to significant T1 positive enhancement in the vascular system
Alternatively, benefit from GadoSpin F:
- For efficient lymph node and inflammation imaging based on its selective enrichment
- By easily performing an additional angiography scan during GadoSpin F's extended blood pool phase
Relaxivity (37 °C, 1.5 T)
r1 = 18 L mmol-1 s-1
r2 = 31 L mmol-1 s-1
r1 = 15 L mmol-1 s-1
r2 = 20 L mmol-1 s-1
~1,300 g mol-1
Schematic diagram of GadoSpin F:
Top: Accumulation of GadoSpin F in atherosclerotic plaque of a WHHL rabbit 6 hours (left) and 24 h (right) post injection, as measured by as measured by T1-weighted MRI (TFL IR, 1.5 T).
Bottom: Axial Flash MR images of an ApoE-/-mouse pre (left) and 24 hours post (right) injection of GadoSpin F. The signal intensity of thr descending aorta (red arrows) increases due to GadoSpin F accumulation in atherosclerotic plaque.
- Jung, C. et al. (2017) Quantitative and qualitative estimation of atherosclerotic plaque burden in vivo at 7T MRI using Gadospin F in comparison to en face preparation evaluated in ApoE KO mice. PlosOne 12(8).
- Christiansen, S.I. (2015) Quantitative Diagnostik und Monitoring sowie qualitative Charakterisierung atherosklerotischer Plaques in ApoE-KO-Mäusen in der MRT mittels GadoSpin F im Vergleich zu μCT und
en face-Präparation. PhD thesis.
- Niessen, H. G. et al. (2011) Visualizing atherosclerotic plaques in mice with a lipophilic MR contrast agent. International Society for Magnetic Resonance Imaging in Medicine Meeting, Montreal, Canada.
- Zheng, J. et al. (2008) Targeted contrast agent helps to monitor advanced plaque during progression: a magnetic resonance imaging study in rabbits. Invest. Radiol. 43: 49-55.