FeraSpin R

Liver imaging MRI agent

Order no:

FeraSpin R MRI agent (1 x 5 injections): 130 - 095 - 138
FeraSpin R MRI agent (5 x 5 injections): 130 - 095 - 139

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price per item:
280.00
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FeraSpin R nanoparticles form the basis of all size-selected FeraSpin products and therefore contain all particles comprising the FeraSpin Series. FeraSpin R is rapidly taken up by liver and spleen macrophages.

Viscover's proven superparamagnetic iron oxide nanoparticle (SPIO) agent:

  • Consists of nanoparticles from 10 - 90 nanometers
  • Is rapidly taken up by macrophages in the liver and spleen
  • Delivers optimal T2/T2* contrast
  • FeraSpin R is Viscover's leading MRI agent for liver and spleen imaging

Apply FeraSpin R SPIO nanoparticles:

  • To effectively visualize spleen, liver and liver tumor morphology in excellent detail
  • To study nanoparticle physiology with ease
  • And rely on a substance well-proven in clinical practice
Physico-chemical properties and structure

Mean particle size (hydrodynamic diameter):

60 nm

Particle size range:

10 - 90 nm

Relaxivity (37 °C, 1.41 T)
In water:

r1 = 10 L mmol-1 s-1
r2 = 185 L mmol-1 s-1

Relaxivity (37 °C, 1.5 T, clinical device)
In plasma:

r1 = 7 L mmol-1 s-1
r2 = 95 L mmol-1 s-1

In water:

r1 = 9 L mmol-1 s-1
r2 = 61 L mmol-1 s-1

Schematic diagram of a FeraSpin R nanoparticle

Schematic diagram of a FeraSpin R nanoparticle

FeraSpin R MRI of the liver
FeraSpin R accumulated in mouse liver Kupffer cells leading to T2* hypointensity of healthy liver tissue and rendering the tumor white and highly visible.
Selected references
  1. Reichardt, W. et al. (2013) Phase Contrast MR Imaging to Image Bacterial translocation in a Mouse Model for Graft versus Host Disease. Proc. Intl. Soc. Mag. Reson. Med. 21, Salt Lake City, Utah, USA.
  2. Lawaczeck, R. et al. (1997) magnetic iron oxide particle coated with carboxydextran for parental administration and liver contrasting. Pre-clinical profile of SHU555A. Acta Radiol 38: 584-597.
  3. Murakami,T. et al. (2001) Evaluation of regional liver damage by magnetic resonance imaging with superparamagnetic iron oxide in rat liver. Dig. Dis. Sci. 46: 148-155.