FeraSpin XS is an ultra-small super-paramagnetic iron oxide nanoparticle agent for MR angiography (MRA). It has been size-selected from FeraSpin R and is part of the FeraSpin Series. FeraSpin XS has the longest circulation time of the entire FeraSpin product family and can be imaged by both T1- (positive contrast) and T2/T2*- weighted sequences.
Viscover’s unique ultrasmall superparamagnetic iron oxide nanoparticle (USPIO) agent:
- Is analogous to human clinical agents
- Has an ultra-small size of 18 nanometers
- Has the longest blood half-life of all FeraSpin products
- Delivers optimal vascular T1 positive enhancement
- FeraSpin XS is Viscover’s leading agent for nanoparticle-based vascular studies
Apply FeraSpin XS to effectively:
- Visualize and quantify vascularization of tumors and inflammatory processes
- Determine the vascular volume fraction and conduct vessel size imaging
Physico-chemical properties and structure
Mean particle size (hydrodynamic diameter):
18 nm
Particle size range:
Narrow size distribution
Relaxivity (37 °C, 1.41 T)
In water:
r1 = 13 L mmol-1 s-1
r2 = 49 L mmol-1 s-1
Relaxivity (37 °C, 1.5 T, clinical device)
In plasma:
r1 = 11 L mmol-1 s-1
r2 = 38 L mmol-1 s-1
In water:
r1 = 13 L mmol-1 s-1
r2 = 44 L mmol-1 s-1
FeraSpin™ XS MR angiography
Mouse whole-body T1-weighted MR angiography using FeraSpin XS.
Selected references
- Allkemper, T. et al. (2002) Contrast enhanced blood-pool MR angiography with optimized iron oxides effect of size and dose on vascular contrast enhancement in rabbits. Radiology 223: 432-438.
- Persigehl, T. et al. (2007) Antiangiogenic tumor treatment: early noninvasive monitoring with USPIO-enhanced MR imaging in mice. Radiology 244: 449-456.
- Persigehl, T. et al. (2007) Prediction of antiangiogenic treatment efficacy by iron oxide enhanced parametric magnetic resonance imaging. Invest. Radiol. 42: 791-796.
Further information