NiraWave M is a unique micellar formulation of NiraWave C with a long circulation time ideal for optical angiography and the study of vascular leakage in inflamming (e.g. rheumatic disease) and tumors. It has a high apparent molecular weight and stays confined in healthy vasculature for more than one hour (mice), while it passes through fenestrated blood vessels.
NiraWave M, the unique micellar optical imaging agent based on indocyanine green (ICG):
- Has a high micellar molecular weight
- Stays confined within healthy blood vessels
- Exits from fenestrated blood vessels, for example, in inflammation
- Viscover's leading optical imaging agent for visualization of vascular fine structure and leakage
- Study inflammatory processes such as rheumatic disease
- Utilize its profound blood pool effect for general vascular studies
660 - 790 nm
Schematic diagram of indocyanine green (ICG) micelles
Normalized absorption and emission spectra of NiraWave M in plasma
Top: Mouse ear optical angiography with NiraWave M shows superior circulation time over ICG standard dye.
Bottom: Inflammation imaging in a rheumatoid arthritis rat model (right) versus the control animal (left) based on NiraWave M vascular leakage.
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- Meyer, J. et al. (2014) In Vivo Imaging of a New Indocyanine Green Micelle Formulation in an Animal Model of Laser-Induced Choroidal Neovascularization. IOVS 55: 6204-6212.