NiraWave M is a micellar formulation of the clinically proven near-infrared fluorescence dye indocyanine green (ICG). Due to the unique formulation, NiraWave M exhibits a stronger fluorescence, higher aqueous stability and prolonged blood circulation time. It is optimized for fluorescence angiography, particularly for the visualization of the microcirculation.
Profit from the optical blood pool imaging agent NiraWave M:
- Highlight vascular structures
- Benefit from the strong and long-lasting blood vessel contrast allowing studies of the microcirculation
- Benefit from the deep tissue penetration
- The high aqueous stability prevents rapid fluorescence decay of the ICG molecule
- Viscover's leading optical imaging agent for visualization of vascular fine structures
Apply NiraWave M to:
- Effectively visualize vascular structures down to the microvessel level
- Perform ophthalmic angiography e.g. in studies of choroidal neovascularization (CNV)
- Monitor therapeutic response
660 - 790 nm
Schematic diagram of indocyanine green (ICG) micelles
Normalized absorption and emission spectra of NiraWave M in plasma
Top: Eye angiograms of rats with laser-induced choroidal vascularization (CNV) before and after injection of NiraWave M. Compared to conventional ICG, NiraWave M provides a significantly higher fluorescent signal that persists for a longer period of time.
Bottom: Inflammation imaging in a rheumatoid arthritis rat model (right) versus the control animal (left) based on NiraWave M vascular leakage.
- Kirchherr, A.K. et al. (2009) Stabilization of indocyanine green within micellar systems. Mol. Pharmaceutics.
- Kirchherr, A.K. (2010) Entwicklung und Charakterisierung neuer kolloidaler Formulierungen für Indocyaningrün als Kontrastmittel für die optische Bildgebung. PhD thesis.
- Schwenck, J. et al. (2016) Fluorescence and Cerenkov luminescence imaging. Nuklearmedizin 55(2): 63–70.
- Meyer, J. et al. (2012) In Vivo Imaging Of A New Indocyanine Green Nanoformulation In An Animal Model.
IOVS 53: 4991.
- Meyer, J. et al. (2014) In Vivo Imaging of a New Indocyanine Green Micelle Formulation in an Animal Model of Laser-Induced Choroidal Neovascularization. IOVS 55: 6204-6212.