NiraWave M

Optical agent for imaging of inflammation

Order no:

NiraWave M optical imaging agent (1 x 5 injections): 130 - 095 - 156
NiraWave M optical imaging agent (5 x 5 injections): 130 - 095 - 157

Unit
price per item:
€395.00
Excluding VAT and shipping costs

NiraWave M is an innovative micellar formulation of the clinically proven near-infrared fluorescence dye indocyanine green (ICG). Due to the unique formulation, NiraWave M exhibits a stronger fluorescence, higher aqueous stability and prolonged blood circulation time. It is ideal for optical angiography and is particularly suited for the visualization of vascular leakage in inflammation (e.g. in rheumatic diseases).

NiraWave M, the unique optical imaging agent:

  • Has a high apparent molecular weight
  • Stays confined within healthy blood vessels
  • Exits from fenestrated blood vessels, for example in inflammation
  • Viscover's leading optical imaging agent for visualization of inflammation

Apply NiraWave M to:

  • Study inflammatory processes such as in rheumatic diseases
  • Benefit from the strong and long-lasting blood vessel contrast allowing studies of the microcirculation
  • Monitor therapeutic response
Physico-chemical properties and structure
Micelle size:

11 nm

Emission wavelength:

830 nm

Excitation wavelength:

660 - 790 nm

Schematic diagram of indocyanine green (ICG) micelles



Normalized absorption and emission spectra of NiraWave M in plasma

NiraWave M optical imaging of inflammation and microcirculation
Eye angiograms of rats with laser-induced choroidal vascularization (CNV) before and after injection of NiraWave M. Compared to conventional ICG, NiraWave M provides a significantly higher fluorescent signal that persists for a longer period of time.
Inflammation imaging in a rheumatoid arthritis rat model...
...versus the control animal (left) based on NiraWave M vascular leakage.

Top: Eye angiograms of rats with laser-induced choroidal vascularization (CNV) before and after injection of NiraWave M. Compared to conventional ICG, NiraWave M provides a significantly higher fluorescent signal that persists for a longer period of time.

Bottom: Inflammation imaging in a rheumatoid arthritis rat model (right) versus the control animal (left) based on NiraWave M vascular leakage.

Selected references
  1. Kirchherr, A.K. et al. (2009) Stabilization of indocyanine green within micellar systems. Mol. Pharmaceutics.
    6: 480–491.
  2. Kirchherr, A.K. (2010) Entwicklung und Charakterisierung neuer kolloidaler Formulierungen für Indocyaningrün als Kontrastmittel für die optische Bildgebung. PhD thesis.
  3. Schwenck, J. et al. (2016) Fluorescence and Cerenkov luminescence imaging. Nuklearmedizin 55(2): 63–70.
  4. Meyer, J. et al. (2012) In Vivo Imaging Of A New Indocyanine Green Nanoformulation In An Animal Model.
    IOVS 53: 4991.
  5. Meyer, J. et al. (2014) In Vivo Imaging of a New Indocyanine Green Micelle Formulation in an Animal Model of Laser-Induced Choroidal Neovascularization. IOVS 55: 6204-6212.