NiraWave M

Optical inflammation imaging agent

Order no:

NiraWave M optical imaging agent (1 x 5 injections): 130 - 095 - 156
NiraWave M optical imaging agent (5 x 5 injections): 130 - 095 - 157

Quantity
Unit
price per item:
380.00
Excluding VAT and shipping costs
Add to cart

NiraWave M is a unique micellar formulation of NiraWave C with a long circulation time ideal for optical angiography and the study of vascular leakage in inflamming (e.g. rheumatic disease) and tumors. It has a high apparent molecular weight and stays confined in healthy vasculature for more than one hour (mice), while it passes through fenestrated blood vessels.

NiraWave M, the unique micellar optical imaging agent based on indocyanine green (ICG):

  • Has a high micellar molecular weight
  • Stays confined within healthy blood vessels
  • Exits from fenestrated blood vessels, for example, in inflammation
  • Viscover's leading optical imaging agent for visualization of vascular fine structure and leakage
  • Study inflammatory processes such as rheumatic disease
  • Utilize its profound blood pool effect for general vascular studies
Physico-chemical properties and structure
Micelle size:

11 nm

Emission wavelength:

830 nm

Excitation wavelength:

660 - 790 nm

Schematic diagram of indocyanine green (ICG) micelles



Normalized absorption and emission spectra of NiraWave M in plasma

NiraWave M optical angiography and inflammation imaging
Mouse ear optical angiography with NiraWave M shows superior circulation time over ICG standard dye.
Inflammation imaging in a rheumatoid arthritis rat model...
...versus the control animal (left) based on NiraWave M vascular leakage.

Top: Mouse ear optical angiography with NiraWave M shows superior circulation time over ICG standard dye.

Bottom: Inflammation imaging in a rheumatoid arthritis rat model (right) versus the control animal (left) based on NiraWave M vascular leakage.

Selected references
  1. Kirchherr, A.K. et al. (2009) Stabilization of indocyanine green within micellar systems. Mol. Pharmaceutics.
    6: 480–491.
  2. Kirchherr, A.K. (2010) Entwicklung und Charakterisierung neuer kolloidaler Formulierungen für Indocyaningrün als Kontrastmittel für die optische Bildgebung. PhD thesis.
  3. Schwenck, J. et al. (2016) Fluorescence and Cerenkov luminescence imaging. Nuklearmedizin 55(2): 63–70.
  4. Meyer, J. et al. (2012) In Vivo Imaging Of A New Indocyanine Green Nanoformulation In An Animal Model.
    IOVS 53: 4991.
  5. Meyer, J. et al. (2014) In Vivo Imaging of a New Indocyanine Green Micelle Formulation in an Animal Model of Laser-Induced Choroidal Neovascularization. IOVS 55: 6204-6212.

 
Further information