ExiTron nano 6000

Liver imaging CT agent

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ExiTron nano 6000 CT contrast agent (1 x 5 injections): 130 - 095 - 146
ExiTron nano 6000 CT contrast agent (5 x 5 injections): 130 - 095 - 147

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ExiTronTM nano 6000 is an innovative nanoparticle agent for liver imaging, the detection of liver tumors and metastases. It is quickly phagocytosed by Kupffer cells and allows hepatic visualization for several weeks after injection.

A unique CT agent for efficacious liver imaging:

  • Optimal for accumulation in the liver and spleen delivering superior contrast
  • Typical injection volume of 100 µL in mice greatly enhances its cardiovascular tolerability
  • Long liver retention enables hepatic imaging for several weeks after a single injection
  • Exitron nano 6000 is Viscover’s leading CT agent for the visualization of
    liver morphology

Apply ExiTron nano 6000 to:

  • Effectively investigate nanoparticles uptake and liver morphology from hours to weeks
  • Detect tumors/metastases in your animal model and quantitate tumor burden with ease and discover its clear advantage over existing agents
Physico-chemical properties and structure
Mean hydrodynamic diameter:

~110 nm

Hounsfield units (undiluted agent):

~6000 HU

Schematic diagram of an ExiTron nano 6000 nanoparticle

ExiTron nano 6000 CT of liver and liver metastases
Progression of mouse liver metastases over the period of 14 days monitored in micro-CT following a single administration of ExiTron nano 6000. The individual lobes of the liver tissue appear clearly opacified.
Selected references
  1. Boll, H. et al. (2011) Micro-CT based experimental liver imaging using a nanoparticulate contrast agent longitudinal study in mice. PLoS ONE 6: e25692.
  2. Kishida, N. et al. (2016) Development of a novel mouse model of hepatocellular carcinoma with nonalcoholic steatohepatitis using a high-fat, cholinedeficient diet and intraperitoneal injection of diethylnitrosamine. BMC Gastroenterol. 16(1): 61.
  3. Rothe, J.H. et al. (2015) Time Course of Contrast Enhancement by Micro-CT with Dedicated Contrast Agents in Normal Mice and Mice with Hepatocellular Carcinoma. Acad. Radiol. 22(2): 169-178.
  4. Hua, X.W. et al. (2015) Contrast-enhanced micro-computed tomography using ExiTron nano 6000 for assessment of liver injury. World J Gastroenterol 21(26): 8043-8051.