GadoSpin M

Proven extracellular MRI agent

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GadoSpin M MRI contrast agent (1 x 5 injections): 130 - 095 - 134
GadoSpin M MRI contrast agent (5 x 5 injections): 130 - 095 - 135

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GadoSpin M is our all-purpose extracellular gadolinium chelate agent for classical contrast-enhanced MRI and for studying CNS diseases. The trusted standard from human clinical MRI has been formulated for small animal imaging.

The trusted all-purpose MRI agent from clinical practice:

  • Is rapidly distributed in vascular and interstitial space
  • Does not permeate membranes or the intact blood-brain barrier
  • GadoSpin M is Viscover's tried and tested extracellular MRI agent

Rely on a substance that is well-proven in clinical practice for the:

  • Investigation of blood-brain barrier abnormalities in brain tumors and neuroinflammation
  • Delineation of tissues based on its differential distribution
Physico-chemical properties and structure

Relaxivity (37 °C, 1.5T)

In plasma:

r1 = 4 L mmol-1 s-1
r2 = 5 L mmol-1 s-1

In water:

r1 = 3 L mmol-1 s-1
r2 = 4 L mmol-1 s-1

Molecular weight:

938 g mol-1

Structural formula of Gd-DTPA:

GadoSpin M brain tumor and whole body MRI
DCE-MRI-based tumor therapy monitoring using GadoSpin D. The effect of anti-angiogenic treatment in mice is studied as contrast agent uptake in regions of tumor angiogenesis. Comparing T1-weighted pre- and post-contrast scans, the contrast effect appears to be significantly lower (and restricted to the cortex region) in treated mice as compared to control mice. This can be attributed to a treatment-induced reduction of neovasculature.
Schematic representation of DCE-MRI using GadoSpin D. Tumor tissue exhibits a significantly higher extravasation of the agent than the reference muscle tissue. Temporal sampling allows for exact quantification and calculation of exchange rate constants.
Top Series:
Intracranial tumor in mouse exhibits contrast enhancement after GadoSpin M has passed the compromised blood-brain barrier. The image series shows tumor progression.
Bottom Series:
Mouse whole body images offer enhanced soft-tissue contrast by using GadoSpin M. Three slices of the dataset are shown.
Selected references
  1. Kiessling, F. et al. (2003) Dynamic T1-weighted monitoring of vascularization in human carcinoma heterotransplants by magnetic resonance imaging. Int. J. Cancer 104: 113-120.
  2. Furman-Haran, E. et al. (1996) Angiogenic response of MCF7 human breast cancer to hormonal treatment: assessment by dynamic GdDTPA-enhanced MRI at spatial resolution. J. Magn. Reson. Imaging 6: 195-202.
  3. Bjørnaes, I. et al. (2000) Measurement of the extracellular volume of human melanoma xenografts by contrast enhanced magnetic resonance imaging. Magn. Reson. Imaging 18: 41-48.

 
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