ExiTron nano 12000

CT angiography agent

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ExiTron nano 12000 CT contrast agent (1 x 5 injections): 130 - 095 - 698
ExiTron nano 12000 CT contrast agent (5 x 5 injections): 130 - 095 - 700

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ExiTron nano 12000 is an innovative nanoparticle agent optimized for high-resolution CT angiography. As the counterpart of ExiTron nano 6000, ExiTron nano 12000 simultaneously also allows for liver imaging and the detection of liver tumors and metastases.

The unique agent for high-resolution CT angiography:

  • Delivers unprecedented contrast
  • Has a long blodd helf-life, remaining in healthy vasculature for a prolonged period of time
  • Enables high resolution vessel imaging through a longer steady state period
  • Passes through fenestrated blood vessels in tumors and inflamed tissue
  • ExiTron nano 12000 is Viscover's leading agent for high-resolution CT angiography
  • Utilize the clear advantage of ExiTron nano 12000 to:

    • Study vascular structures down to the microvessel level
    • Visualize vascular abnormalities in tumors and inflammation
    • Profit from the liver imaging capability analogous to ExiTron nano 6000
    Physico-chemical properties and structure
    Mean hydrodynamic diameter:

    ~110 nm

    Hounsfield units (undiluted agent):

    ~12000 HU

    Schematic diagram of an ExiTron nano 12000 nanoparticle

    ExiTron nano 12000 CT angiography
    Left: CT angiography of a mouse using ExiTron nano 12000 showing the heart and vascular fine structure. Right: 3D volume-rendered CT of a mouse head showing the extracranial vasculature after administration of ExiTron nano 12000.
    Selected references
    1. Das, N.M. et al. (2016) In Vivo Quantitative Microcomputed Tomographic Analysis of Vasculature and Organs in a Normal and Diseased Mouse Model. PLoS One 11(2): e0150085.
    2. Lalwani, K. et al. (2013) Contrast Agents for Quantitative MicroCT of Lung Tumors in Mice. Comp Med. 63(6): 482-90.
    3. Zhu, G. et al. (2019) In Vivo Detection and Measurement of Aortic Aneurysm and Dissection in Mouse Models Using Microcomputed Tomography with Contrast Agent. Contrast Media Mol. Imaging: 5940301.
    4. Liu, C.-N. et al. (2019) Nanoparticle contrast-enhanced micro-CT: A preclinical tool for the 3D imaging of liver and spleen in longitudinal mouse studies. J. Pharmacol. Toxicol. Methods. 96: 67-77.
    Further information