Monitoring clearance of brain waste
Visualization of brain waste clearance pathways using dynamic contrastenhanced (DCE) MRI and GadoSpinTM P
In this study we demonstrate that the CSF-ISF exchange pathway, responsible for clearance of wastes from the brain, can be assessed using dynamic contrast-enhanced MRI. Implementation of the polymeric MRI agent, GadoSpin P, in comparison to the small-molecule MRI agent, Magnevist, enabled not only visualization of CSF and ISF flow, but also examination of the size-dependence of flow behaviour.
To download the application sheet (PDF) please click on the image!