Stem cell labeling
In this study we report on highly effective and biocompatible iron oxide nanoparticles for in vitro stem cell labeling with optimized contrast properties for MRI and MPS. The particle characteristics allow a direct labeling without the use of any transfection agents or other additional treatments, which is favorable for the future development of clinical applications. The optimal iron uptake characteristics enable the use of external magnetic fields to influence the labeled cells, allowing not only their homing to a specific target but also capturing of the labeled stem cells in vivo.
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