Monitoring clearance of brain waste

GadoSpin P

Visualization of brain waste clearance pathways using dynamic contrastenhanced (DCE) MRI and GadoSpinTM P

In this study we demonstrate that the CSF-ISF exchange pathway, responsible for clearance of wastes from the brain, can be assessed using dynamic contrast-enhanced MRI. Implementation of the polymeric MRI agent, GadoSpin P, in comparison to the small-molecule MRI agent, Magnevist, enabled not only visualization of CSF and ISF flow, but also examination of the size-dependence of flow behaviour.

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