NiraWave M

Optical inflammation imaging agent

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NiraWave M optical imaging agent (1 x 5 injections): 130 - 095 - 156
NiraWave M optical imaging agent (5 x 5 injections): 130 - 095 - 157

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380.00
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NiraWave M is a micellar formulation of the clinically proven near-infrared fluorescence dye indocyanine green (ICG). Due to the unique formulation, NiraWave M exhibits a stronger fluorescence, higher aqueous stability and prolonged blood circulation time. It is optimized for fluorescence angiography, particularly for the visualization of the microcirculation.

Profit from the optical blood pool imaging agent NiraWave M:

  • Highlight vascular structures
  • Benefit from the strong and long-lasting blood vessel contrast allowing studies of the microcirculation
  • Benefit from the deep tissue penetration
  • The high aqueous stability prevents rapid fluorescence decay of the ICG molecule
  • Viscover's leading optical imaging agent for visualization of vascular fine structures

Apply NiraWave M to:

  • Effectively visualize vascular structures down to the microvessel level
  • Perform ophthalmic angiography e.g. in studies of choroidal neovascularization (CNV)
  • Monitor therapeutic response
Physico-chemical properties and structure
Micelle size:

11 nm

Emission wavelength:

830 nm

Excitation wavelength:

660 - 790 nm

Schematic diagram of indocyanine green (ICG) micelles



Normalized absorption and emission spectra of NiraWave M in plasma

NiraWave M optical angiography and imaging of the microcirculation
Eye angiograms of rats with laser-induced choroidal vascularization (CNV) before and after injection of NiraWave M. Compared to conventional ICG, NiraWave M provides a significantly higher fluorescent signal that persists for a longer period of time.
Inflammation imaging in a rheumatoid arthritis rat model...
...versus the control animal (left) based on NiraWave M vascular leakage.

Top: Eye angiograms of rats with laser-induced choroidal vascularization (CNV) before and after injection of NiraWave M. Compared to conventional ICG, NiraWave M provides a significantly higher fluorescent signal that persists for a longer period of time.

Bottom: Inflammation imaging in a rheumatoid arthritis rat model (right) versus the control animal (left) based on NiraWave M vascular leakage.

Selected references
  1. Kirchherr, A.K. et al. (2009) Stabilization of indocyanine green within micellar systems. Mol. Pharmaceutics.
    6: 480–491.
  2. Kirchherr, A.K. (2010) Entwicklung und Charakterisierung neuer kolloidaler Formulierungen für Indocyaningrün als Kontrastmittel für die optische Bildgebung. PhD thesis.
  3. Schwenck, J. et al. (2016) Fluorescence and Cerenkov luminescence imaging. Nuklearmedizin 55(2): 63–70.
  4. Meyer, J. et al. (2012) In Vivo Imaging Of A New Indocyanine Green Nanoformulation In An Animal Model.
    IOVS 53: 4991.
  5. Meyer, J. et al. (2014) In Vivo Imaging of a New Indocyanine Green Micelle Formulation in an Animal Model of Laser-Induced Choroidal Neovascularization. IOVS 55: 6204-6212.