PolySon agents have been optimized for organ perfusion measurements and visualization of the liver and spleen. They are the only agents available that are suited for stimulated acoustic emission imaging (SAE) based on inducible bubble rupture.
PolySon, the unique hard-shell ultrasound microbubbles:
- Are highly echogenic at all typically used frequencies
- Deliver optimal contrast in all typical ultrasound methods, even above 30 MHz
- Visualize organ perfusion at HF ultrasound microscopic resolutions
- Apply Viscover's leading ultrasound contrast agents for organ perfusion
- Benefit from the only ultrasound contrast agents on the market with added capabilities for stimulated acoustic emission (SAE/SPAQ) methods
Optimized for high acoustic pressures
All purpose and recommended for low acoustic pressure methods, e.g. organ perfusion
Schematic diagram of a polymeric microbubble
Left: Liver imaging based on stimulated acousting emission using PolySon H. The pseudo-doppler effect resulting from the rupture of single bubbles can be seen in red and blue false-color.
Right: Heart perfusion in mouse using PolySon L. The three frames from the video clip show the filling of the heart with contrast agent in green false-color.
- Reinhardt, M. et al. (2005) Sensitive particle acoustic quantification (SPAQ): a new ultrasound-based approach for the quantification of ultrasound contrast media in high concentrations. Invest. Radiol. 40: 2-7.
- Tiemann, K. et al. (2000) Stimulated acoustic emission: pseudo-doppler shifts seen during the destruction of nonmoving microbubbles. Ultrasound Med. Biol. 26: 1161-1167.
- Hauff, P. et al. (2004) Molecular targeting of lymph nodes with L-selectin ligand-specific US contrast agent: a feasibility study in mice and dogs. Radiology 231: 667-673.